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With an oral supplement, the B12 needs to be absorbed through your digestive system first before getting to your blood, which takes a lot longer
To support this metabolic process, some clinicians recommend co-supplementation with a methyl donor such as trimethylglycine (TMG) while on NAD+ injections
The mechanism is proposed to involve G-protein coupled receptor signaling, but definitive identification of the functional receptor has not been published
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